3-Amino-1-methyl-5-phenyl-1H-benzo[E][1,4]diazepin-2(3H)-one → N-(3,5-Difluoro-benzyl)-2-ethyl-N'-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-malonamide

反応式

[F:21][c:22]1[cH:23][c:24]([CH2:25][NH:26][C:27]([CH:28]([C:29](=[O:30])[OH:31])[CH2:32][CH3:33])=[O:34])[cH:35][c:36]([F:38])[cH:37]1.[NH2:1][CH:2]1[C:3](=[O:20])[N:4]([CH3:19])[c:5]2[c:6]([cH:15][cH:16][cH:17][cH:18]2)[C:7]([c:9]2[cH:10][cH:11][cH:12][cH:13][cH:14]2)=[N:8]1>>[NH:1]([CH:2]1[C:3](=[O:20])[N:4]([CH3:19])[c:5]2[c:6]([cH:15][cH:16][cH:17][cH:18]2)[C:7]([c:9]2[cH:10][cH:11][cH:12][cH:13][cH:14]2)=[N:8]1)[C:29]([CH:28]([C:27]([NH:26][CH2:25][c:24]1[cH:23][c:22]([F:21])[cH:37][c:36]([F:38])[cH:35]1)=[O:34])[CH2:32][CH3:33])=[O:30]

参加物

反応物 2

HCID 27296813-Amino-1-methyl-5-phenyl-1H-benzo[E][1,4]diazepin-2(3H)-one

HCID 69280647N-(3,5-Difluoro-benzyl)-2-ethyl-malonamic acid

生成物 1

HCID 10481236N-(3,5-Difluoro-benzyl)-2-ethyl-N'-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-malonamide

出典と根拠

ORDレコード: ord-0b95e8fb02a046459bef7f99b7cad4aa
出典データセット: Training data from https://doi.org/10.1039/C8SC04228D (4/10)
DOI: 10.1039/C8SC04228D

反応ノート

読み込み中…