Hydrochloric Acid → Ethyl 2-methoxyethanecarboximidate hydrochloride

HRID 216236

反応式

HRID 216236 の反応式
[ClH:1].[CH3:2][O:3][CH2:4][C:5]#[N:6].[CH3:7][CH2:8][OH:9]>C(OCC)C>[ClH:1].[CH2:8]([O:9][C:5](=[NH:6])[CH2:4][O:3][CH3:2])[CH3:7]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 74442Methoxyacetonitrile

生成物 1

HCID 12816254Ethyl 2-methoxyethanecarboximidate hydrochloride収率 87%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

反応条件

温度
-10 °C

実験手順

Hydrochloric acid gas is bubbled through a solution of methoxyacetonitrile (26 g, 0.37 mol) in EtOH (22 mL) and diethyl ether (118 mL), which is chilled to −10° C. for twenty minutes. The reaction vessel is capped and stirred for 17 hours at ambient temperature. The mixture is cooled to −10° C. The solid that forms is collected by filtration, washed with diethyl ether and air dried to afford 2-methoxy-acetimidic acid ethyl ester hydrochloride (49.3 g, 87%) as a solid.

後処理

  1. customThe reaction vessel is capped
  2. temperatureThe mixture is cooled to −10° C
  3. filtrationThe solid that forms is collected by filtration
  4. washwashed with diethyl ether and air
  5. customdried

出典と根拠

ORDレコード
ord-374557f2bc98456dbbed958ff9f54c3d
出典データセット
uspto-grants-2012_06
特許番号
US08193183B2

関連ノート

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