化工社化工社 化学情報印刷レポート · 研究参考用
Water → N-(6-bromo-1,3-benzothiazol-2-yl)acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Acetyl chloride | HCID 6367 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2-Benzothiazolamine, 6-bromo- | HCID 85149 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | N-(6-bromo-1,3-benzothiazol-2-yl)acetamide | HCID 3240669 | 74% |
反応手順
To a solution of 2-amino-6-bromobenzothiazole (10 g, 43.65 mmol) and triethylamine (12.2 mL, 87.3 mmol) and N,N-dimethylaminopyridine (269 mg) in THF (100 mL) is added acetyl chloride (4.7 mL). After stirring for 17 hours water (100 mL) is added and the mixture is extracted twice with EtOAc (75 mL). The organic extracts are combined and dried over magnesium sulfate, filtered and concentrated to afford N-(6-bromo-benzothiazol-2-yl)-acetamide (8.79 g, 74%) as a solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08193183B2 |
| 出典データセット | uspto-grants-2012_06 |
| ORD ID | ord-31a0b31931a844cf9ba68387e50535f3 |
| 出典メモ | uspto-grants-2012_06 |