Chloromethyl Methyl Ether → N-methoxymethyl-N'-t-butyl-N,N'-dibenzoylhydrazine

HRID 21630

反応式

HRID 21630 の反応式
[C:1]([N:5]([C:15](=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[NH:6][C:7](=[O:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:23][O:24][CH2:25]Cl>S([O-])(O)(=O)=O.C([N+](CCCC)(CCCC)CCCC)CCC.C1(C)C=CC=CC=1>[CH3:23][O:24][CH2:25][N:6]([C:7](=[O:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[N:5]([C:1]([CH3:4])([CH3:2])[CH3:3])[C:15](=[O:22])[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

参加物

5

反応物 2

HCID 7864Chloromethyl Methyl EtherHCID 863071,2-Dibenzoyl-1-(tert-butyl)hydrazine

生成物 1

HCID 15294609N-methoxymethyl-N'-t-butyl-N,N'-dibenzoylhydrazine

試薬・触媒・溶媒 2

HCID 94433Tetrabutylammonium hydrogen sulfate触媒HCID 1140Toluene溶媒

実験手順

N'-t-butyl-N,N'-dibenzoylhydrazine (2 g, 0.007M) was stirred at room temperature in a two phase system of toluene-50% sodium hydroxide with 100 mg of phase transfer catalyst (tetra-n-butylammonium hydrogen sulfate). Methoxymethyl chloride (1.2 g, 0.015M) was added dropwise and the mixture was stirred 3 hours. The layers were separated and the toluene layer was washed several times with water (until the water washes were neutral). The toluene solution was dried over anhydrous magnesium sulfate and the toluene removed under vacuum to afford N-methoxymethyl-N'-t-butyl-N,N'-dibenzoylhydrazine as a thick oil.

後処理

  1. customThe layers were separated
  2. washthe toluene layer was washed several times with water (until the water washes
  3. dry with materialThe toluene solution was dried over anhydrous magnesium sulfate
  4. customthe toluene removed under vacuum

出典と根拠

ORDレコード
ord-7d2cb3f08be145dbb405d7662fdadc8f
出典データセット
uspto-grants-1995_06
特許番号
US05424333

関連ノート

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