4-Chloro-2-nitroanisole → 5-Chloro-2-methoxyaniline

HRID 2163200

反応式

HRID 2163200 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[C:4]([N+:10]([O-])=O)[CH:3]=1>[Ni]>[NH2:10][C:4]1[CH:3]=[C:2]([Cl:1])[CH:7]=[CH:6][C:5]=1[O:8][CH3:9]

参加物

3

反応物 1

HCID 666314-Chloro-2-nitroanisole

生成物 1

HCID 667635-Chloro-2-methoxyaniline

試薬・触媒・溶媒 1

HCID 935Nickel触媒

実験手順

0.037 mol (7 g) of 4-chloro-2-nitroanisole is dissolved in 100 ml of absolute alcohol and 3 g of nickel prepared by the RANEY process are added. The solution is hydrogenated at atmospheric pressure and at room temperature while stirring. The catalyst is separated and then washed with two portions of 20 ml of boiling ethanol. The alcoholic solution is concentrated under reduced pressure; the 2-amino-4-chloroanisole crystallizes.

後処理

  1. additionare added
  2. customis hydrogenated at atmospheric pressure and at room temperature
  3. customThe catalyst is separated
  4. washwashed with two portions of 20 ml of boiling ethanol
  5. concentrationThe alcoholic solution is concentrated under reduced pressure
  6. customthe 2-amino-4-chloroanisole crystallizes

出典と根拠

ORDレコード
ord-c028b86f410243dba402322e62916b94
出典データセット
uspto-grants-1979_01
特許番号
US04132786

関連ノート

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