関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Bromopyridine | HCID 7973 | — |
| 反応物 | Potassium Fluoride | HCID 522689 | — |
| 反応物 | Hexamethylditin | HCID 6327618 | — |
| 反応物 | 1-(5-Bromopyridin-2-yl)ethan-1-one | HCID 23145345 | — |
| 触媒 | Tetrakis(triphenylphosphine)palladium | HCID 11979704 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 1-(5-Fluoro-2,3'-bipyridin-6'-yl)ethanone | HCID 59162014 | — |
反応手順
Palladium tetrakis(triphenylphosphine) (289 mg, 0.25 mmol) was added to a degassed, ambient temperature solution of 2-bromopyridine (660 mg, 3.75 mmol), 1-(5-bromo-pyridin-2-yl)-ethanone (500 mg, 2.5 mmol) and hexamethylditin (1.2 g, 3.75 mmol) in degassed 1,4-dioxane (8 mL). After stirring at 110° C. overnight, the reaction mixture was cooled and KF/celite (1:1) was added. After stirring vigorously for 1 hr, reaction mixture was filtered and concentrated. Chromatography over silica eluting with 0-50% ethyl acetate/hexane afforded the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08193228B2 |
|---|
| 出典データセット | uspto-grants-2012_06 |
|---|
| ORD ID | ord-43d217c3562947fcb3f9a7548c588cb2 |
|---|
| 出典メモ | uspto-grants-2012_06 |
|---|
