Hydrochloric Acid → HCID 70580866、化合物

反応式

S(=O)(=O)(O)[OH:2].[C:6]1([C:12]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)([CH:15]2[CH2:18][N:17]([CH3:19])[CH2:16]2)[C:13]#[N:14])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[ClH:26]>CC(CC(C)C)=O>[ClH:26].[C:6]1([C:12]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)([CH:15]2[CH2:18][N:17]([CH3:19])[CH2:16]2)[C:13]([NH2:14])=[O:2])[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

参加物

反応条件

温度: 70 °C

実験手順

To 60 ml. of concentrated sulfuric acid preheated to 60° C. was added 21.7 g. (0.082 mole) of α,α-diphenyl-α-(1-methyl-3-azetidinyl)acetonitrile at a rate so as to maintain a temperature of 60°-70° C. The solution obtained was heated to 70° C. for 18 hrs. and extracted with chloroform. The chloroform extract was dried over sodium sulfate and concentrated and the residue crystallized from ethyl acetate-isopropyl alcohol to give 13.8 g. of the free base (60%) melting at 171°-174° C. The base was treated with hydrogen chloride in isobutyl methyl ketone and the salt recrystallized from isopropyl alcohol to give 9 g. of product melting at 182°-185° C.