Triethylamine → 4-(2,2-dimethylpropyl)-N,N-dimethyl-1H-imidazole-1-sulfonamide
反応式
[CH3:1][C:2]([CH3:10])([CH3:9])[CH2:3][C:4]1[NH:8][CH:7]=[N:6][CH:5]=1.[CH3:11][N:12]([CH3:17])[S:13](Cl)(=[O:15])=[O:14].CCN(CC)CC>C(Cl)Cl.CN(C1C=CN=CC=1)C>[CH3:1][C:2]([CH3:10])([CH3:9])[CH2:3][C:4]1[N:8]=[CH:7][N:6]([S:13]([N:12]([CH3:17])[CH3:11])(=[O:15])=[O:14])[CH:5]=1参加物
6
実験手順
A solution of 5-(2,2-dimethylpropyl)-1H-imidazole, dimethylsulfamoyl chloride (25 mL), Et3N (45 mL) in CH2Cl2 (300 mL) was added DMAP (0.8 g). The reaction mixture was refluxed overnight. The solvent was evaporated and the residue was purified by silica gel chromatography to give the title compound as a white solid.
後処理
- temperatureThe reaction mixture was refluxed overnight
- customThe solvent was evaporated
- customthe residue was purified by silica gel chromatography
出典と根拠
- ORDレコード
- ord-fce201cbc7b94f32b75c1ac10287c823
- 出典データセット
- uspto-grants-2012_06
- 特許番号
- US08193228B2
反応ノート
読み込み中…