Hydrochloric Acid → HCID 178505637、化合物

HRID 2163476ノート

反応式

HRID 2163476 の反応式
[OH-].[K+].[CH:3]([NH:5][NH:6][C:7]([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[F:16])=[S:8])=O.Cl>O>[F:16][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[N:9]1[CH:3]=[N:5][N:6]=[C:7]1[SH:8]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 2390670Hydrazinecarbothioamide, N-(2-fluorophenyl)-2-formyl-

生成物 1

HCID 178505637HCID 178505637、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

One and one-tenth grams (20 mmoles) of potassium hydroxide were dissolved in 50 ml. of water. 1-Formyl-4-(2-fluorophenyl)thiosemicarbazide, 3.5 g. (16.5 mmoles), was dissolved in the basic solution by warming on the steam bath until solution was completed. The heating was continued for 1 hour. The cooled reaction mixture was poured into a dilute solution of hydrochloric acid. The insoluble product was recovered from the acidic solution by filtration. The product was washed with water, collected and dried. The yield was 2.5 g. of 4-(2-fluorophenyl)-1,2,4-triazole-3-thiol, m.p. about 166°-167° C.

後処理

  1. dissolution(16.5 mmoles), was dissolved in the basic solution
  2. temperatureby warming on the steam bath until solution
  3. customThe cooled reaction mixture
  4. filtrationThe insoluble product was recovered from the acidic solution by filtration
  5. washThe product was washed with water
  6. customcollected
  7. customdried

出典と根拠

ORDレコード
ord-5a0fbb38506c4fa3828e93901c43fe57
出典データセット
uspto-grants-1979_01
特許番号
US04134914

反応ノート

読み込み中…