関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | Acetic-formic anhydride | HCID 75269 | — |
| 反応物 | Sodium Acetate | HCID 517045 | — |
| 反応物 | 2-Bromo-1,3-thiazol-4-amine--hydrogen bromide (1/1) | HCID 20294041 | — |
| 溶媒 | Formic Acid | HCID 284 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 2-Bromo-4-formamidothiazole | HCID 20294036 | 58% |
反応手順
Acetic anhydride (100 ml) was cooled to 0° C. and treated with 98% formic acid (50 ml.). The resulting mixture was heated at 50° C. for 15 minutes then cooled to 0° C. To this solution of formic-acetic anhydride was added 4-amino-2-bromothiazole hydrobromide (26 g, 0.1 m) followed dropwise by pyridine (25 ml.). The reaction mixture was allowed to stand for 1 hour at room temperature then poured onto 20% aqueous sodium acetate solution (500 ml). The resulting crystals were removed by filtration, washed once with water (100 ml) then recrystallised from ethanol to give the 2-bromo-4-formamidothiazole (12 g, 58%). m.p. 167° C. d. (Found: C, 23.55; H, 1.6; N, 13.45. C4H3N2BrOS requires C, 23.2; H, 1.45; N, 13.5%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04134984 |
|---|
| 出典データセット | uspto-grants-1979_01 |
|---|
| ORD ID | ord-e70a790fb4a84e349129e891279d4390 |
|---|
| 出典メモ | uspto-grants-1979_01 |
|---|
