Diethyl Oxalate → Ethyl benzo[g]quinazolin-4(3H)-one-2-carboxylate

HRID 2163596ノート

反応式

HRID 2163596 の反応式
[C:1]([O:8][CH2:9][CH3:10])(=[O:7])[C:2](OCC)=O.C[O-].[Na+].[NH2:14][C:15]1[C:24]([C:25]([NH2:27])=[O:26])=[CH:23][C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH:16]=1>>[N:14]1[C:15]2[C:24](=[CH:23][C:22]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[CH:16]=2)[C:25](=[O:26])[NH:27][C:2]=1[C:1]([O:8][CH2:9][CH3:10])=[O:7]

参加物

4

反応物 3

HCID 7268Diethyl OxalateHCID 10942334Sodium MethoxideHCID 124714773-aMino-2-naphthaMide

生成物 1

HCID 135961510Ethyl benzo[g]quinazolin-4(3H)-one-2-carboxylate収率 79%

実験手順

Diethyl oxalate (2.35 g., 16.1 millimoles), sodium methoxide (10 m and 2-aminonaphthalene-3-carboxamide (1.50 g., 8.05 millimoles) are mixed together and heated at reflux for two days. The mixture is then cooled in an ice bath and the brown precipitate recovered by filtration. It is recrystallized from ethanol to give 1.76 g. (79% yield) of the desired ester. M.P. 240°-242° C.

後処理

  1. temperatureheated
  2. temperatureat reflux for two days
  3. temperatureThe mixture is then cooled in an ice bath
  4. filtrationthe brown precipitate recovered by filtration
  5. customIt is recrystallized from ethanol
  6. customto give 1.76 g

出典と根拠

ORDレコード
ord-8ec7e8b688d04959a3a575517991d0d9
出典データセット
uspto-grants-1979_01
特許番号
US04134981

反応ノート

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