Hydrochloric Acid → 4-(p-Anilinophenoxy)butyric acid
反応式
[NH:1]([C:8]1[CH:21]=[CH:20][C:11]([O:12][CH2:13][CH2:14][CH2:15][C:16]([O:18]C)=[O:17])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].Cl>CN(C)C=O>[NH:1]([C:8]1[CH:21]=[CH:20][C:11]([O:12][CH2:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17])=[CH:10][CH:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1参加物
5
実験手順
Methyl 4-(p-anilinophenoxy)butyrate prepared by the method of Example 1 was hydrolyzed in a mixture of aqueous potassium carbonate and N,N-dimethylformamide. The reaction mixture was acidified with hydrochloric acid and the solids precipitated thereby were collected and recrystallized from ethanol. The 4-(p-anilinophenoxy)butyric acid thus obtained was a greyish crystalline solid, m.p. 110°-111° C.