Hydrochloric Acid → 2-(Phenethylhydrazono)-propionic acid

HRID 2163684ノート

反応式

HRID 2163684 の反応式
[CH2:1]([NH:9][N:10]=[C:11]([CH3:17])[C:12]([O:14]CC)=[O:13])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[OH-].[K+].C(O)C.Cl>C(OCC)C.O>[CH2:1]([NH:9][N:10]=[C:11]([CH3:17])[C:12]([OH:14])=[O:13])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14797Potassium HydroxideHCID 73183671Ethyl 2-(phenethylhydrazono)-propionate

生成物 1

HCID 1942362-(Phenethylhydrazono)-propionic acid収率 47%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 3283Diethyl Ether溶媒

実験手順

6 g. Ethyl 2-(phenethylhydrazono)-propionate (prepared according to Example 2) are dissolved in a solution of 1.4 g. potassium hydroxide in 28 ml. 80% ethanol and saponified at ambient temperature. After stirring for 30 hours, the reaction mixture is mixed with 25 ml. water and shaken out twice with 50 ml. amounts of diethyl ether. The aqueous phase is acidified with dilute hydrochloric acid. The crystals which precipitate out are filtered off and recrystallized from toluene. There is obtained 2-(phenethylhydrazono)-propionic acid in a yield of 47% of theory; m.p. 74°-76° C.

後処理

  1. customsaponified at ambient temperature
  2. additionthe reaction mixture is mixed with 25 ml
  3. customThe crystals which precipitate out
  4. filtrationare filtered off
  5. customrecrystallized from toluene

出典と根拠

ORDレコード
ord-5d37c66fcbf04311a25a4636bf89f1cc
出典データセット
uspto-grants-1979_01
特許番号
US04136196

反応ノート

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