Timonacic → 3-[4-(Hexadecylamino)benzoyl]-4-carboxythiazolidine

HRID 2163771

反応式

HRID 2163771 の反応式
[CH2:1]([NH:17][C:18]1[CH:35]=[CH:34][C:21]([C:22]([N:24]2[CH:28]([C:29]([O:31]CC)=[O:30])[CH2:27][S:26][CH2:25]2)=[O:23])=[CH:20][CH:19]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].S1CC(C(O)=O)NC1>C(=O)(O)[O-].[Na+].CC(C)=O>[CH2:1]([NH:17][C:18]1[CH:19]=[CH:20][C:21]([C:22]([N:24]2[CH:28]([C:29]([OH:31])=[O:30])[CH2:27][S:26][CH2:25]2)=[O:23])=[CH:34][CH:35]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

参加物

4

反応物 2

HCID 9934TimonacicHCID 204373423-[4-(Hexadecylamino)benzoyl]-4-carboethoxythiazolidine

生成物 1

HCID 204373653-[4-(Hexadecylamino)benzoyl]-4-carboxythiazolidine

試薬・触媒・溶媒 1

HCID 86737261Acetone sodium bicarbonate溶媒

実験手順

By means of the alkaline hydrolysis method of Example 7, the ethyl ester of Example 21 is converted to the subject carboxylic acid. This acid is also prepared using the procedure of Example 21 except that the acylation of the thiazolidine-4-carboxylic acid is carried out in aqueous acetone sodium bicarbonate solution.

後処理

  1. customBy means of the alkaline hydrolysis method of Example 7
  2. customThis acid is also prepared

出典と根拠

ORDレコード
ord-5b11191574bb446b90494df4117a7bc3
出典データセット
uspto-grants-1979_01
特許番号
US04136256

関連ノート

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