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Hydrochloric Acid → N-[4-(hexadecylamino)benzoyl]-2-aminoethanesulfonic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Taurine | HCID 1123 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | N-[N-trifluoroacetyl-4-(hexadecylamino)benzoyloxy]succinimide | HCID 20437360 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | N-[4-(hexadecylamino)benzoyl]-2-aminoethanesulfonic acid | HCID 20437369 | — |
反応手順
To a stirred solution of 2.50 g. of taurine and 5.6 ml. of triethylamine in 22.5 ml. of water is added 5.55 g. of N-[p-(2,2,2-trifluoro-N-hexadecylacetamido)benzoyloxy]succinimide as a solution in 45 ml. of ethanol. After 24 hours, the mixture is treated with 20 ml. of 2.0M sodium hydroxide and 25 ml. of water. After stirring for 10 min., the mixture is acidified with dilute hydrochloric acid, and the crude product is collected by filtration. Recrystallization affords the title compound as a white solid, m.p. 190°-220° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04136256 |
| 出典データセット | uspto-grants-1979_01 |
| ORD ID | ord-f377ed7c16e14487b3f13d1ce25884d8 |
| 出典メモ | uspto-grants-1979_01 |