Phthalimide → N-methyl-N'-[3-(4-methyl-2-oxazolyl)thiopropyl]thiourea
反応式
C1(=O)NC(=O)C2=CC=CC=C12.NN.[CH3:14][N:15]=[C:16]=[S:17].[CH3:18][C:19]1[N:20]=[C:21]([S:24][CH2:25][CH2:26][CH2:27][NH:28]C(N)=S)[O:22][CH:23]=1>>[CH3:14][NH:15][C:16]([NH:28][CH2:27][CH2:26][CH2:25][S:24][C:21]1[O:22][CH:23]=[C:19]([CH3:18])[N:20]=1)=[S:17]参加物
5
実験手順
Treatment of the phthalimide compound (3.0 g.) with hydrazine (1.53 g.) followed by reaction of the product directly with methyl isothiocyanate (0.73 g.) using the conditions described in Example 132 afforded N-methyl)-N-[3-(4-methyl-2-oxazolyl)thiopropyl]thiourea (1.0 g.). m.p. 73°-74° (from ethanol-ether-n-hexane).
出典と根拠
- ORDレコード
- ord-62fa46014e2640698d84a9d45967b214
- 出典データセット
- uspto-grants-1979_01
- 特許番号
- US04137234
反応ノート
読み込み中…