Aziridine → 4-[3-(1-Aziridinyl)-2-hydroxypropoxy]-9-fluorenone

反応式

[O:1]1[CH2:19][CH:2]1[CH2:3][O:4][C:5]1[C:17]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10](=[O:18])[C:9]=2[CH:8]=[CH:7][CH:6]=1.[CH2:20]1[NH:22][CH2:21]1>>[N:22]1([CH2:19][CH:2]([OH:1])[CH2:3][O:4][C:5]2[C:17]3[C:16]4[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=4)[C:10](=[O:18])[C:9]=3[CH:8]=[CH:7][CH:6]=2)[CH2:20][CH2:21]1

参加物

反応物 2

HCID 9033Aziridine

HCID 18678486HCID 18678486、化合物

生成物 1

HCID 227502124-[3-(1-Aziridinyl)-2-hydroxypropoxy]-9-fluorenone

実験手順

4 g of 4-(2,3-epoxypropoxy)-9-fluorenone are allowed to stand at room temperature over night together with 15 cc of ethylene imine. The excess ethylene imine is removed by evaporation, the residue is taken up in ether and the solution is concentrated by evaporation until crystallization commences. The title compound has an M.P. of 113°-116°.

後処理

customThe excess ethylene imine is removed by evaporation
concentrationthe solution is concentrated by evaporation until crystallization commences

出典と根拠

ORDレコード: ord-cf3d26869e524948b945c135cbe522b5
出典データセット: uspto-grants-1979_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04137331

反応ノート

読み込み中…

参加物