Hydrochloric Acid → Methyl 4-bromo-alpha-hydroxybenzeneacetate

HRID 216414

反応式

HRID 216414 の反応式
Cl.[Br:2][C:3]1[CH:13]=[CH:12][C:6]([CH:7]([OH:11])[C:8]([OH:10])=[O:9])=[CH:5][CH:4]=1.[CH3:14]O>>[Br:2][C:3]1[CH:13]=[CH:12][C:6]([CH:7]([OH:11])[C:8]([O:10][CH3:14])=[O:9])=[CH:5][CH:4]=1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 97930p-Bromomandelic acid

生成物 1

HCID 14571696Methyl 4-bromo-alpha-hydroxybenzeneacetate

実験手順

Hydrogen chloride (4 M in 1,4-dioxane) (3 mL, 18 mmol) was added to an ambient temperature solution of 4-bromomandelic acid (5 g, 21.6 mmol) in methanol (50 mL). After stirring at ambient temperature overnight, the reaction mixture was concentrated in vacuo to afford methyl (4-bromophenyl)(hydroxy)acetate which was used in the subsequent step without further purification.

後処理

  1. concentrationthe reaction mixture was concentrated in vacuo

出典と根拠

ORDレコード
ord-533bddb034934f46ba8c10cbee45ebb7
出典データセット
uspto-grants-2012_06
特許番号
US08193228B2

関連ノート

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