Piperidin-3-ylmethanol → 1-(4-Acetylbenzenesulfonyl)-3-piperidinemethanol

HRID 2164155ノート

反応式

HRID 2164155 の反応式
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10](Cl)(=[O:12])=[O:11])=[CH:6][CH:5]=1)(=[O:3])[CH3:2].C(C1C=CC(S([O-])(=O)=O)=CC=1)(=O)C.[Na+].[NH:28]1[CH2:33][CH2:32][CH2:31][CH:30]([CH2:34][OH:35])[CH2:29]1>O>[C:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10]([N:28]2[CH2:33][CH2:32][CH2:31][CH:30]([CH2:34][OH:35])[CH2:29]2)(=[O:12])=[O:11])=[CH:6][CH:5]=1)(=[O:3])[CH3:2]

参加物

5

反応物 3

HCID 107308Piperidin-3-ylmethanolHCID 2664184-Acetylbenzenesulfonyl chlorideHCID 23668814Sodium 4-acetylbenzenesulphonate

生成物 1

HCID 49859811-(4-Acetylbenzenesulfonyl)-3-piperidinemethanol

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

The damp 4-acetylbenzenesulfonyl chloride from 100 g. of sodium 4-acetylbenzenesulfonate is added to a solution of 114 g. of 3-piperidinemethanol in 900 ml. of water. The mixture is stirred at room temperature for 16 hours, cooled, and the precipitate of 1-(4-acetylbenzenesulfonyl)-3-piperidinemethanol collected by filtration, washed with water and dried; m.p. 104°-106° C. after crystallization from aqueous ethanol.

後処理

  1. temperaturecooled
  2. filtrationthe precipitate of 1-(4-acetylbenzenesulfonyl)-3-piperidinemethanol collected by filtration
  3. washwashed with water
  4. customdried
  5. customm.p. 104°-106° C. after crystallization from aqueous ethanol

出典と根拠

ORDレコード
ord-e9444900983343888ef6960dac51e35c
出典データセット
uspto-grants-1979_01
特許番号
US04137408

反応ノート

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