Hydrochloric Acid → 7-(2-Fluorobenzoyl)-indolin-2-one

HRID 2164299ノート

反応式

HRID 2164299 の反応式
[F:1][C:2]1[CH:21]=[CH:20][CH:19]=[CH:18][C:3]=1[C:4]([C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:14]=1[NH:13][C:12](=[O:15])[CH:11]2SC)=[O:5].[Sn].Cl>C(O)C>[F:1][C:2]1[CH:21]=[CH:20][CH:19]=[CH:18][C:3]=1[C:4]([C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:14]=1[NH:13][C:12](=[O:15])[CH2:11]2)=[O:5]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 5352426Tin atomHCID 133942837-(2-Fluorobenzoyl)-3-(methylsulfanyl)-1,3-dihydro-2H-indol-2-one

生成物 1

HCID 133942867-(2-Fluorobenzoyl)-indolin-2-one収率 60.7%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 60 g (0.2 mole) of 7-(2-fluorobenzoyl)-3-methylthioindolin-2-one and 60 g (0.5 mole) of tin powder in one liter of 95% ethanol was heated to reflux and 150 ml of concentrated hydrochloric acid was added. Heating was continued for 18 hrs, then the mixture was cooled and the precipitate was collected by decanting the slurry from the remaining tin and filtering the slurry. The filter cake was recrystallized twice from absolute ethanol to give 31 g (60%) white needles, m.p. 209°-210° C.

後処理

  1. temperaturewas heated
  2. temperatureto reflux
  3. temperatureHeating
  4. temperaturethe mixture was cooled
  5. customthe precipitate was collected
  6. customby decanting the slurry from the remaining tin
  7. filtrationfiltering the slurry
  8. customThe filter cake was recrystallized twice from absolute ethanol

出典と根拠

ORDレコード
ord-9c96ec57725541ba8227d135cad2204b
出典データセット
uspto-grants-1985_03
特許番号
US04503073

反応ノート

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