関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | N'-tert-butylbenzohydrazide | HCID 299436 | — |
| 反応物 | Isonicotinoyl chloride hydrochloride | HCID 12262826 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | N'-t-butyl-N-benzoyl-N'-isonicotinoylhydrazine | HCID 15767540 | — |
反応手順
N'-t-butyl-N-benzoylhydrazine (1.0 g, 0.0052 mol) was suspended in 20 ml of toluene. Isonicotinoyl chloride hydrochloride (0.93 g, 0.0052 mol) was added and then a solution of sodium hydroxide (1.25 g of 50% aqueous NaOH) in 5 ml of water was added dropwise. After stirring at 23° C. for 2 hours, the solids were removed by filtration, washed with water and dried in air. The crude product was chromatographed on silica gel using 5% methanol/methylene chloride as eluant to afford pure N'-t-butyl-N-benzoyl-N'-isonicotinoylhydrazine: m.p. >210° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US05424333 |
|---|
| 出典データセット | uspto-grants-1995_06 |
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| ORD ID | ord-8743c2d7a9fc42ab9163b98b5f3b12a5 |
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| 出典メモ | uspto-grants-1995_06 |
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