3-Ethoxy-4-phenyl-4H-furo[3,2-b]indole-2-carboxamide → 3-Ethoxy-4-phenyl-4H-furo[3,2-b]indole-2-carbonitrile

HRID 2164341ノート

反応式

HRID 2164341 の反応式
[CH2:1]([O:3][C:4]1[C:8]2[N:9]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=3[C:7]=2[O:6][C:5]=1[C:22]([NH2:24])=O)[CH3:2]>O>[CH2:1]([O:3][C:4]1[C:8]2[N:9]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=3[C:7]=2[O:6][C:5]=1[C:22]#[N:24])[CH3:2]

参加物

3

反応物 1

HCID 132203983-Ethoxy-4-phenyl-4H-furo[3,2-b]indole-2-carboxamide

生成物 1

HCID 133941643-Ethoxy-4-phenyl-4H-furo[3,2-b]indole-2-carbonitrile収率 91%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Prepared by the procedure described in Example 21 from 6.5 g (0.020 mole) of 3-ethoxy-4-phenyl-4H-furo[3,2-b]indole-2-carboxamide. The crude product (5.5 g, 90% yield), after being washed with water and dried, was converted to the corresponding tetrazole without additional purification. A portion of the crude nitrile recrystallized from methanol yielded an analytically pure sample, mp 121°-122° C.

後処理

  1. customPrepared by the procedure

出典と根拠

ORDレコード
ord-ffc6f526c5034650bf80ee33eb650126
出典データセット
uspto-grants-1985_03
特許番号
US04503236

反応ノート

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