2-Chloro-5-(trifluoromethyl)pyridine → 2-Chloro-5-trichloromethylpyridine

HRID 2164453

反応式

HRID 2164453 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](F)(F)F)=[CH:4][N:3]=1.[Cl-:12].[Al+3].[Cl-:14].[Cl-:15]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([Cl:15])([Cl:14])[Cl:12])=[CH:4][N:3]=1

参加物

3

反応物 2

HCID 923422-Chloro-5-(trifluoromethyl)pyridineHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 502932-Chloro-5-trichloromethylpyridine

実験手順

To 18.2 g of 2-chloro-5-trifluoromethyl pyridine, 20 g of aluminum chloride was added in 2 hours, and they were reacted under the predetermined reaction conditions as shown in Table 1. After the completion of the reaction, the reaction product was cooled and then introduced into ice water, and the oil layer was separated by liquid separation. The solvent was removed by distillation to obtain 2-chloro-5-trichloromethyl pyridine.

後処理

  1. customthey were reacted under the predetermined reaction conditions
  2. customAfter the completion of the reaction
  3. temperaturethe reaction product was cooled
  4. customthe oil layer was separated by liquid separation
  5. customThe solvent was removed by distillation

出典と根拠

ORDレコード
ord-d59167c8efd6400badb46632f1a2389d
出典データセット
uspto-grants-1985_03
特許番号
US04504665

関連ノート

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