2-Chloronicotinic acid → 2-Chloro-3-(trichloromethyl)pyridine

反応式

[Cl:1][C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](O)=O.ClC1C(C(F)(F)F)=CC=CN=1.[Cl-:22].[Al+3].[Cl-:24].[Cl-:25]>>[Cl:1][C:2]1[C:3]([C:4]([Cl:25])([Cl:24])[Cl:22])=[CH:7][CH:8]=[CH:9][N:10]=1

参加物

反応物 3

HCID 762582-Chloronicotinic acid

HCID 5898332-Chloro-3-(trifluoromethyl)pyridine

HCID 6451240Aluminum(III) Chloride

生成物 1

HCID 6066982-Chloro-3-(trichloromethyl)pyridine

実験手順

The process according to claim 4 wherein 2-chloronicotinic acid is produced by reacting 2-chloro-3-trifluoromethyl pyridine with aluminum chloride to obtain 2-chloro-3-trichloromethyl pyridine and then hydrolyzing the 2-chloro-3-trichloromethyl pyridine in the presence of sulfuric acid or phosphoric acid.

後処理

customis produced

出典と根拠

ORDレコード: ord-f34ae5676ea5471cb14ee6c9600fb57c
出典データセット: uspto-grants-1985_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04504665

反応ノート

読み込み中…