Water → 5-t-Butyl-3-cyclobutanecarbonylaminopyrazole

HRID 2164503ノート

反応式

HRID 2164503 の反応式
[NH2:1][C:2]1[CH:6]=[C:5]([C:7]([CH3:10])([CH3:9])[CH3:8])[NH:4][N:3]=1.C(N(CC)CC)C.[CH:18]1([C:22](Cl)=[O:23])[CH2:21][CH2:20][CH2:19]1.O>C(Cl)Cl.C(Cl)(Cl)(Cl)Cl>[C:7]([C:5]1[NH:4][N:3]=[C:2]([NH:1][C:22]([CH:18]2[CH2:21][CH2:20][CH2:19]2)=[O:23])[CH:6]=1)([CH3:10])([CH3:9])[CH3:8]

参加物

7

反応物 4

HCID 962WaterHCID 8471TriethylamineHCID 78705Cyclobutanecarbonyl chlorideHCID 5227873-Amino-5-tert-butylpyrazole

生成物 1

HCID 134770005-t-Butyl-3-cyclobutanecarbonylaminopyrazole

試薬・触媒・溶媒 2

HCID 5943Carbon Tetrachloride溶媒HCID 6344Dichloromethane溶媒

実験手順

4.3 g (0.03 mole) of 3-amino-5-t-butylpyrazole as prepared in Example 1 and 3 g of triethylamine were dissolved in 30 ml of methylene chloride. To this solution was added dropwise 3.6 g of cyclobutanecarboxylic acid chloride dissolved in 30 ml of carbon tetrachloride. The resulting mixture was allowed to stand at room temperature over night. Thereafter, water was added thereto followed by shaking it. Crystals thus formed were collected by filtration and washed with water and carbon tetrachloride to obtain 5-t-butyl-3-cyclobutanecarbonylaminopyrazole.

後処理

  1. waitto stand at room temperature over night
  2. customCrystals thus formed
  3. filtrationwere collected by filtration
  4. washwashed with water and carbon tetrachloride

出典と根拠

ORDレコード
ord-7b86865510af4e1e9851b0c31e5ea268
出典データセット
uspto-grants-1985_03
特許番号
US04505739

反応ノート

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