Hydrochloric Acid → 2-(4-Carbomethoxy-2,6-dichlorophenylimino)imidazolidine

HRID 2164621ノート

反応式

HRID 2164621 の反応式
C([N:4]1[CH2:8][CH2:7][NH:6][C:5]1=[N:9][C:10]1[C:15]([Cl:16])=[CH:14][C:13]([C:17]([O:19][CH3:20])=[O:18])=[CH:12][C:11]=1[Cl:21])(=O)C.Cl>CO.C(Cl)Cl.CO>[C:17]([C:13]1[CH:12]=[C:11]([Cl:21])[C:10]([N:9]=[C:5]2[NH:6][CH2:7][CH2:8][NH:4]2)=[C:15]([Cl:16])[CH:14]=1)([O:19][CH3:20])=[O:18]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 178498045HCID 178498045、化合物

生成物 1

HCID 1784980442-(4-Carbomethoxy-2,6-dichlorophenylimino)imidazolidine収率 81%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 21226129Dichloromethane methanol溶媒

実験手順

A solution of 1-acetyl-2-(4-carbomethoxy-2,6-dichlorophenylimino)imidazolidine (5 g, 15 mmole) and 2M hydrochloric acid (1 ml, 2 mmole) in methanol (100 ml) was heated under reflux for 40 hour. The mixture was then evaporated to give a solid which was taken up in methylene chloride/methanol (650 ml:30 ml) and extracted with saturated sodium carbonate (300 ml). The organic layer was dried and evaporated to give a residue which after trituration with ether, yielded the title compound as a solid (3.5 g) mp 229°-231° C.

後処理

  1. temperatureunder reflux for 40 hour
  2. customThe mixture was then evaporated
  3. customto give a solid which
  4. extractionextracted with saturated sodium carbonate (300 ml)
  5. customThe organic layer was dried
  6. customevaporated
  7. customto give a residue which after trituration with ether

出典と根拠

ORDレコード
ord-ae0fd9ca595147109262e189854a9fd2
出典データセット
uspto-grants-1985_03
特許番号
US04505926

反応ノート

読み込み中…