Tert-butyl 2-nitrobenzoate → tert-Butyl 2-aminobenzoate

HRID 2164681ノート

反応式

HRID 2164681 の反応式
[N+:1]([C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[C:6]([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:7])([O-])=O>CO.[C].[Pd]>[NH2:1][C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[C:6]([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:7]

参加物

4

反応物 1

HCID 4860715Tert-butyl 2-nitrobenzoate

生成物 1

HCID 3430448tert-Butyl 2-aminobenzoate収率 887.3%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

実験手順

A mixture of tert-butyl 2-nitrobenzoate (2.1 g.) in methanol (200 ml.) was hydrogenated over palladium-carbon (2 g.) with shaking at atmospheric pressure and room temperature for 3.5 hours. The reaction mixture was filtered to remove the catalyst and then evaporated. To the residue were successively added diethyl ether and an aqueous solution of sodium chloride followed by shaking. The organic layer was separated, dried over magnesium sulfate, treated with activated charcoal and then evaporated to give an oil of the title compound (16.13 g.).

後処理

  1. filtrationThe reaction mixture was filtered
  2. customto remove the catalyst
  3. customevaporated
  4. stirringby shaking
  5. customThe organic layer was separated
  6. dry with materialdried over magnesium sulfate
  7. additiontreated with activated charcoal
  8. customevaporated

出典と根拠

ORDレコード
ord-6574e45b1c90479882da78f4532fb22a
出典データセット
uspto-grants-1985_03
特許番号
US04506076

反応ノート

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