2-Azaspiro[5.5]undec-1-ene → 2-Azaspiro[5.5]undecane

HRID 2164727ノート

反応式

HRID 2164727 の反応式
[CH:1]1[C:6]2([CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]2)[CH2:5][CH2:4][CH2:3][N:2]=1.[H][H]>[Ni].C(O)C>[CH2:1]1[C:6]2([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]2)[CH2:5][CH2:4][CH2:3][NH:2]1

参加物

5

反応物 2

HCID 18835922-Azaspiro[5.5]undec-1-eneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 50061172-Azaspiro[5.5]undecane収率 88.1%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 702Ethanol溶媒

実験手順

A solution of 2-azaspiro-[5.5]-undec-1-ene (15 g.; 0.10 mole) and one teaspoon (3 g.) of W2 Raney nickel catalyst in absolute ethanol (300 ml.) is hydrogenated at an initial pressure of B 40 psi until hydrogen uptake ceases (2 hours). The mixture is filtered through celite and the filtrate concentrated under reduced pressure. Distillation of the residual liquid yields 88% of 2-azaspiro-[5.5]-undecane (13.5 g.), b.p. 55°-57° C./0.10 mm.

後処理

  1. filtrationThe mixture is filtered through celite
  2. concentrationthe filtrate concentrated under reduced pressure
  3. distillationDistillation of the residual liquid

出典と根拠

ORDレコード
ord-33e67b5e3a984a11be32cc748201282a
出典データセット
uspto-grants-1985_03
特許番号
US04507291

反応ノート

読み込み中…