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1,3-Dibromopropane → 6-[4-Acetyl-3-(3-bromopropoxy)-2-propylphenoxy]hexanoic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,3-Dibromopropane | HCID 8001 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Methyl 6-(4-acetyl-3-hydroxy-2-propylphenoxy)hexanoate | HCID 14330007 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 6-[4-Acetyl-3-(3-bromopropoxy)-2-propylphenoxy]hexanoic acid methyl ester | HCID 14330008 | 98% |
反応手順
A mixture of 6.0 g of 6-(4-acetyl-3-hydroxy-2-propylphenoxy)hexanoic acid methyl ester, 19 ml of 1,3-dibromopropane and 2.0 g of anhydrous potassium carbonate in 175 ml of anhydrous acetone was stirred at reflux for 52 hours. The reaction mixture was concentrated in vacuo to give 8.1 g (98% yield) of 6-[4-acetyl-3-(3-bromopropoxy)-2-propylphenoxy]hexanoic acid methyl ester as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04507498 |
| 出典データセット | uspto-grants-1985_03 |
| ORD ID | ord-04fa06f1b03748619ec46f58fa210f36 |
| 出典メモ | uspto-grants-1985_03 |