Sodium Cyanide → 2-(6-Methoxyindan-1-yl)acetonitrile
反応式
[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([CH2:7][CH2:8][CH:9]2[CH2:12]OS(C)(=O)=O)=[CH:5][CH:4]=1.[C-:18]#[N:19].[Na+]>CS(C)=O>[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([CH2:7][CH2:8][CH:9]2[CH2:12][C:18]#[N:19])=[CH:5][CH:4]=1参加物
4
実験手順
12.8 g (50 mmol) of methanesulphonic acid (6-methoxyindan-1-ylmethyl) ester and 3.7 g (75 mmol) of sodium cyanide are dissolved in 70 ml of dimethyl sulphoxide and heated at 80° for 6 hours. The reaction mixture is poured onto 200 ml of ice-water and extracted three times by shaking with 100 ml of toluene each time. The organic phases are combined, subsequently washed with saturated sodium chloride solution and dried over magnesium sulphate. After removing the solvent in vacuo, crude 2-(6-methoxyindan-1-yl)acetonitrile is obtained.
後処理
- temperatureheated at 80° for 6 hours
- extractionextracted three times
- washsubsequently washed with saturated sodium chloride solution
- dry with materialdried over magnesium sulphate
- customAfter removing the solvent in vacuo
出典と根拠
- ORDレコード
- ord-a952fad7214e4c9c80c6de6fb950f446
- 出典データセット
- uspto-grants-1990_07
- 特許番号
- US04939160
反応ノート
読み込み中…