Carbon Dioxide → 2,6-Dichloro-3,5-difluorophenol
反応式
[Cl:1][C:2]1[C:3]([F:14])=[C:4]([C:8]([F:13])=[C:9]([Cl:12])[C:10]=1[OH:11])C(O)=O.CN(C)C=O.C(=O)=O.C1(C)C=CC=CC=1>O>[Cl:1][C:2]1[C:3]([F:14])=[CH:4][C:8]([F:13])=[C:9]([Cl:12])[C:10]=1[OH:11]参加物
6
実験手順
50 g of 3,5-dichloro-2,6-difluoro-4-hydroxy-benzoic acid and 10 ml of dimethylformamide are mixed and heated. At 105°-130° C., carbon dioxide evolves, and the reaction is allowed to run to completion at this temperature. 200 ml of toluene and then 80 ml of water are subsequently stirred into the mixture, the phases are separated, and the organic phase is dried and subsequently distilled. 34 g product of boiling point 87°-8° C. are obtained; nD20 : 1.5310.
後処理
- temperatureheated
- customAt 105°-130° C.
- customthe phases are separated
- customthe organic phase is dried
- distillationsubsequently distilled
出典と根拠
- ORDレコード
- ord-0cd1443ef24e4c61b268de8bf0872d8d
- 出典データセット
- uspto-grants-1990_07
- 特許番号
- US04939170
反応ノート
読み込み中…