Methanol → HCID 14326126、化合物

HRID 2165218ノート

反応式

HRID 2165218 の反応式
[C-:1]#[N:2].[Na+].[CH3:4][C:5]1[C:12]([F:13])=[C:11]([F:14])[C:8]([CH:9]=[O:10])=[C:7]([F:15])[C:6]=1[F:16].CO>O>[C:1]([CH:9]([OH:10])[C:8]1[C:7]([F:15])=[C:6]([F:16])[C:5]([CH3:4])=[C:12]([F:13])[C:11]=1[F:14])#[N:2]

参加物

5

反応物 3

HCID 887MethanolHCID 8929Sodium CyanideHCID 132680124-Methyl-2,3,5,6-tetrafluoro-benzaldehyde2 回

生成物 1

HCID 14326126HCID 14326126、化合物収率 99.5%

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

反応条件

温度
0 °C

実験手順

1.66 g of sodium cyanide were introduced into a mixture of 4 g of 4-methyl-2,3,5,6-tetrafluorobenzaldehyde, 4 g of 4-methyl-2,3,5,6-tetrafluorobenzaldehyde, 70 ml of methyl alcohol and 20 ml of water and the mixture was cooled to 0° C. The reaction mixture was stirred for 1 hour at 0° C. and was poured into water. Extraction was carried out with ether and the ethereal phases were dried and evaporated to dryness under reduced pressure to obtain 4.54 g of the product melting at 124° C.

後処理

  1. extractionExtraction
  2. customthe ethereal phases were dried
  3. customevaporated to dryness under reduced pressure

出典と根拠

ORDレコード
ord-14b1c62fa2994ceba94f146d05fa247f
出典データセット
uspto-grants-1990_07
特許番号
US04939172

反応ノート

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