3-Aminopyrrolidine → HCID 18640048、化合物

HRID 2165247ノート

反応式

HRID 2165247 の反応式
[Cl-:1].[K+].[Pt+2:3].[Cl-:4].[Cl-].[NH2:6][CH:7]1[CH2:11][CH2:10][NH:9][CH2:8]1>O>[Pt+2:3].[Cl:1][C@H:8]1[C@@H:7]([NH2:6])[CH2:11][CH2:10][N:9]1[Cl:4]

参加物

4

反応物 2

HCID 1644013-AminopyrrolidineHCID 86744074platinum (II) potassium chloride

生成物 1

HCID 18640048HCID 18640048、化合物収率 67.9%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a solution of platinum (II) potassium chloride, (12.2 g) in water (800 ml) is added (3RS)-3-aminopyrrolidine (2.5 g), and the mixture is stirred at room temperature for 19 hours. The precipitated solid is removed by filtration, and the filtrate is concentrated under reduced pressure. To the residue is added a small amount of water, and the resulting crystals are separated by filtration and washed with water and acetone to give cis-dichloro-(3RS)-3-aminopyrrolidine platinum (II) (6.9 g) as pale yellow crystal.

後処理

  1. customThe precipitated solid is removed by filtration
  2. concentrationthe filtrate is concentrated under reduced pressure
  3. additionTo the residue is added a small amount of water
  4. customthe resulting crystals are separated by filtration
  5. washwashed with water and acetone

出典と根拠

ORDレコード
ord-dc56a559a44b4b9db7ec1c7bc34f7b37
出典データセット
uspto-grants-1990_07
特許番号
US04939256

反応ノート

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