3-(5-Methyl-1,2-oxazol-3-yl)propan-1-ol → 3-(5-Hydroxypentyl)-5-methylisoxazole

反応式

[C:1]([CH2:4][CH2:5][CH2:6][CH2:7][C:8]1(C)[CH:12]=[CH:11][O:10][NH:9]1)([OH:3])=O.[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH3:20]C1ON=C(CCCO)C=1>>[OH:3][CH2:1][CH2:4][CH2:5][CH2:6][CH2:7][C:8]1[CH:12]=[C:11]([CH3:20])[O:10][N:9]=1

参加物

反応物 3

HCID 133169743-(5-Methyl-1,2-oxazol-3-yl)propan-1-ol

HCID 200641073-(4-Carboxybutyl)-3-methylisoxazole

HCID 21226445Aluminium lithium hydride

生成物 1

HCID 133169773-(5-Hydroxypentyl)-5-methylisoxazole収率 84%

実験手順

3-(5-Hydroxypentyl)-5-methylisoxazole was prepared by reduction of 3-(4-carboxybutyl)-3-methylisoxazole with lithium aluminum hydride according to the procedure of part (e) above, and was obtained in 84% yield as an oil, b.p. 115°-125° C.(0.1 mm).