Sulfuric Acid → HCID 20064021、化合物

HRID 2165389ノート

反応式

HRID 2165389 の反応式
S(=O)(=O)(O)O.[Br:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][O:13][C:14]1[CH:24]=[CH:23][C:17]([C:18]([O:20]CC)=[O:19])=[CH:16][CH:15]=1.[OH-].[NH4+]>O>[Br:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][O:13][C:14]1[CH:15]=[CH:16][C:17]([C:18]([OH:20])=[O:19])=[CH:23][CH:24]=1

参加物

5

反応物 3

HCID 1118Sulfuric AcidHCID 14923Ammonium HydroxideHCID 18989362Ethyl p-(6-Bromohexyloxy)benzoate

生成物 1

HCID 20064021HCID 20064021、化合物収率 79.4%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Concentrated sulfuric acid (1036 ml) was added gradually to 338 ml of water, followed by 622 g of ethyl 4-(6-bromohexyloxy)benzoate. The mixture was heated at 100°-110° C. for 35 minutes and then poured onto 2.5 kg ice with stirring. The mixture was treated with 2520 ml of ammonium hydroxide to bring the pH to 6.0. The product was collected by filtration, washed with water and hexane, and dried in an oven to give 452 g of 4-(6-bromohexyloxy)benzoic acid

後処理

  1. temperatureThe mixture was heated at 100°-110° C. for 35 minutes
  2. filtrationThe product was collected by filtration
  3. washwashed with water and hexane
  4. customdried in an oven

出典と根拠

ORDレコード
ord-70139b5504bc40ccad7805cd5a12d292
出典データセット
uspto-grants-1990_07
特許番号
US04939267

反応ノート

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