Methyl 5-methyl-3-isoxazolepropanoate → 5-{8-[2-Chloro-4-(4,5-dihydro-2-oxazolyl)phenoxy]octyl}-3-methylisoxazole
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[O:10][CH2:11][CH2:12][N:13]=2)[CH:5]=[CH:6][C:7]=1[OH:8].Br[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][C:23]1[O:27][N:26]=[C:25]([CH3:28])[CH:24]=1.CC1ON=C(CCC(OC)=O)C=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[O:10][CH2:11][CH2:12][N:13]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][C:23]1[O:27][N:26]=[C:25]([CH3:28])[CH:24]=1参加物
4
実験手順
5-{8-[2-Chloro-4-(4,5-dihydro-2-oxazolyl)phenoxy]octyl}-3-methylisoxazole [IX; R=CH3, R2, R3, R4, R5 and R6 =H, R1 =2-Cl, Y=(CH2)8, oxazole at 4-position] was prepared from 4,5-dihydro-2-(3-chloro-4-hydroxyphenyl)oxazole (Example 13b) and 5-(8-bromooctyl)-3-methylisoxazole (Example 18a) according to the procedure of Example 9, part (d), and was obtained in the form of a colorless solid, m.p. 63°-65° C. when recrystallized from ether.