Acetic Anhydride → HCID 14835102、化合物
反応式
[C:1]([CH:3]1[C:12](=[O:13])[N:11]2[C:6]([CH:7]=[CH:8][CH:9]=[CH:10]2)=[C:5]2[C:14]([CH2:17][CH2:18][CH3:19])=[N:15][N:16]=[C:4]12)#[N:2].[C:20](OC(=O)C)(=[O:22])[CH3:21]>>[C:20]([N:16]1[C:4]2=[C:3]([C:1]#[N:2])[C:12](=[O:13])[N:11]3[C:6]([CH:7]=[CH:8][CH:9]=[CH:10]3)=[C:5]2[C:14]([CH2:17][CH2:18][CH3:19])=[N:15]1)(=[O:22])[CH3:21]参加物
3
実験手順
A mixture of 80 g of 4-cyano-1-propyl-5H-pyrazolo-[4,3-a]quinolizin-5-one (S-1) and 2.0 l of acetic anhydride was heated under reflux for 18 hours. The solvent was evapolated under reduced pressure and the residual crystals were washed with water (0.5 l), methyl alcohol (0.5 l) and chloroform (0.5 l) successively to give 84 g of 3-acetyl-4-cyano-1-propyl-5H-pyrazolo-[4,3-a]quinolizin-5-one as pale yellow crystals.
後処理
- temperaturewas heated
- temperatureunder reflux for 18 hours
- washthe residual crystals were washed with water (0.5 l), methyl alcohol (0.5 l) and chloroform (0.5 l) successively
出典と根拠
- ORDレコード