化工社化工社 化学情報印刷レポート · 研究参考用
7-Chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid → 6-Fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(3-(methoxymethyl)-1-piperazinyl]-4-oxo-3-quinolinecarboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 7-Chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid | HCID 57338 | — |
| 反応物 | 2-(Methoxymethyl)piperazine | HCID 14230264 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 6-Fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(3-(methoxymethyl)-1-piperazinyl]-4-oxo-3-quinolinecarboxylic acid | HCID 14839406 | — |
反応手順
A 906 mg portion of 7-chloro-6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and 1.4 g of 2-(methoxymethyl)piperazine were added to 10 ml of pyridine and reacted as described in Example 81, giving 187 mg of the desired product, mp 216°-218° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04940710 |
| 出典データセット | uspto-grants-1990_07 |
| ORD ID | ord-8125365767bf4ef0b61cfafca36f90ea |
| 出典メモ | uspto-grants-1990_07 |