Sulfuryl chloride → 2-Chloro-1-(3,5-di-tert-butyl-4-hydroxyphenyl)ethan-1-one

HRID 2165736ノート

反応式

HRID 2165736 の反応式
S(Cl)([Cl:4])(=O)=O.[C:6]([C:10]1[CH:11]=[C:12]([C:21](=[O:23])[CH3:22])[CH:13]=[C:14]([C:17]([CH3:20])([CH3:19])[CH3:18])[C:15]=1[OH:16])([CH3:9])([CH3:8])[CH3:7]>C(Cl)Cl>[Cl:4][CH2:22][C:21]([C:12]1[CH:11]=[C:10]([C:6]([CH3:9])([CH3:7])[CH3:8])[C:15]([OH:16])=[C:14]([C:17]([CH3:20])([CH3:19])[CH3:18])[CH:13]=1)=[O:23]

参加物

4

反応物 2

HCID 24648Sulfuryl chlorideHCID 6162963',5'-Bis(tert-butyl)-4'-hydroxyacetophenone

生成物 1

HCID 142109772-Chloro-1-(3,5-di-tert-butyl-4-hydroxyphenyl)ethan-1-one

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

16.2 g (0.12 mol) of sulfuryl chloride in 50 ml of methylene chloride were added dropwise while stirring to a solution of 19.9 g (0.08 mol) of 1-(3,5-di-tert.butyl-4-hydroxyphenyl)-ethanone in 250 ml of methylene chloride at room temperature. After stirring for 3 hours at room temperature, the batch was washed by shaking first with water and then with a saturated sodium hydrogen carbonate solution, and the methylene chloride phase was dried over sodium sulfate and evaporated under reduced pressure.

後処理

  1. washthe batch was washed
  2. stirringby shaking first with water
  3. dry with materialwith a saturated sodium hydrogen carbonate solution, and the methylene chloride phase was dried over sodium sulfate
  4. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-76ee66c018ac4272baa47d8ba1f61b90
出典データセット
uspto-grants-1990_07
特許番号
US04940790

反応ノート

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