Dimethylformamide dimethyl acetal → HCID 53860039、化合物
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([CH3:19])([CH3:18])[C:10](=[O:17])[CH2:11][N:12]2[CH:16]=[N:15][CH:14]=[N:13]2)=[CH:4][CH:3]=1.CO[CH:22](OC)[N:23]([CH3:25])[CH3:24]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([CH3:19])([CH3:18])[C:10](=[O:17])[C:11]([N:12]2[CH:16]=[N:15][CH:14]=[N:13]2)=[CH:22][N:23]([CH3:25])[CH3:24])=[CH:4][CH:3]=1参加物
3
実験手順
50 g (0.18 mol) of 1-(4-chlorophenyl)-2,2-dimethyl-4-(1,2,4-triazol-1-yl)-3-butanone are heated under reflux with 23.6 g (0.138 mol) of dimethylformamide dimethylacetal for 8 hours. To isolate the end product, the reaction mixture is concentrated in vacuo. 56.5 g (94.4% of theory) of 1-(4-chlorophenyl)-2,2-dimethyl-5-dimethylamino-4-(1,2,4-triazol-1-yl)-4-penten-3-one of refractive index n20 1.5797 are obtained. ##STR17##
後処理
- customTo isolate the end product
- concentrationthe reaction mixture is concentrated in vacuo