HCID 14990558、化合物 → HCID 14990559、化合物

HRID 2166030ノート

反応式

HRID 2166030 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]2[CH:15]=[CH:14][C:13]([NH:16][CH:17]([CH3:19])[CH3:18])=[C:12]([N+:20]([O-])=O)[CH:11]=2)=[O:9])=[CH:4][CH:3]=1.[H][H]>[Ni].C(O)C>[NH2:20][C:12]1[CH:11]=[C:10]([C:8]([C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)=[O:9])[CH:15]=[CH:14][C:13]=1[NH:16][CH:17]([CH3:18])[CH3:19]

参加物

5

反応物 2

HCID 14990558HCID 14990558、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 14990559HCID 14990559、化合物収率 92.1%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 702Ethanol溶媒

実験手順

A solution of 14.7 parts of (4-fluorophenyl) [4-[(1-methylethyl)amino]-3-nitrophenyl]methanone in 120 parts of ethanol was hydrogenated at 2.105Pa with 3 parts of Raney nickel catalyst. After the calculated amount of hydrogen was taken up, the catalyst was filtered off over diatomaceous earth and the filtrate was evaporated, yielding 12.3 parts (92.1%) of [3-amino-4-[(1-methylethyl)amino]phenyl](4-fluorophenyl)methanone as a residue (int. 2).

後処理

  1. filtrationthe catalyst was filtered off over diatomaceous earth
  2. customthe filtrate was evaporated

出典と根拠

ORDレコード
ord-d6ffda214e844c3480bb33dc11040f14
出典データセット
uspto-grants-1990_07
特許番号
US04943574

反応ノート

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