4-(Butylamino)-3-nitrobenzoic acid → 3-Amino-4-(butylamino)benzoic acid

HRID 2166034ノート

反応式

HRID 2166034 の反応式
[CH2:1]([NH:5][C:6]1[CH:14]=[CH:13][C:9]([C:10]([OH:12])=[O:11])=[CH:8][C:7]=1[N+:15]([O-])=O)[CH2:2][CH2:3][CH3:4].[H][H]>[Ni].CO>[NH2:15][C:7]1[CH:8]=[C:9]([CH:13]=[CH:14][C:6]=1[NH:5][CH2:1][CH2:2][CH2:3][CH3:4])[C:10]([OH:12])=[O:11]

参加物

5

反応物 2

HCID 28298164-(Butylamino)-3-nitrobenzoic acidHCID 178418361HCID 178418361、化合物

生成物 1

HCID 115502333-Amino-4-(butylamino)benzoic acid収率 100%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

A mixture of 50 parts of 4-(butylamino)-3-nitrobenzoic acid and 240 parts of methanol was hydrogenated in a Parr apparatus at 3.105Pa and at room temperature with 40 parts of Raney Nickel catalyst under nitrogen atmosphere. After the calculated amount of hydrogen was taken up, the catalyst was filtered off over diatomaceous earth and the filtrate was evaporated to dry, yielding 43.7 parts (100%) of 3-amino-4-(butylamino)benzoic acid; mp. 158° C. (int. 8).

後処理

  1. filtrationthe catalyst was filtered off over diatomaceous earth
  2. customthe filtrate was evaporated
  3. customto dry

出典と根拠

ORDレコード
ord-2add87776fcc412899fe956579092135
出典データセット
uspto-grants-1990_07
特許番号
US04943574

反応ノート

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