Benzyl Bromide → N'-t-butyl-N-benzoyl-N'-benzylhydrazine

HRID 21661

反応式

HRID 21661 の反応式
[CH2:1](Br)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:9]([NH:17][NH:18][C:19]([CH3:22])([CH3:21])[CH3:20])(=[O:16])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.C(N(CC)CC)C>CN(C)C=O.C(OCC)C>[C:19]([N:18]([CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[NH:17][C:9](=[O:16])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)([CH3:22])([CH3:21])[CH3:20]

参加物

6

反応物 3

HCID 7498Benzyl BromideHCID 8471TriethylamineHCID 299436N'-tert-butylbenzohydrazide

生成物 1

HCID 15452008N'-t-butyl-N-benzoyl-N'-benzylhydrazine

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 6228Dimethylformamide溶媒

実験手順

Benzyl bromide (0.9 g), 1-benzoyl-2-t-butyl hydrazine (1 g) and triethylamine (0.52 g) were warmed in dimethylformamide (50 ml) at 50° C. for 2 hours. The reaction mixture was cooled to room temperature, diluted with diethylether (100 ml) and washed three times with 25 ml of water. The organic layer was dried over magnesium sulfate, filtered and the solvent removed in vacuo to afford the product as a white solid. The product was chromatographed on silica gel (G:70 to 230 mesh) using methylene chloride as eluant to afford a 75% yield of a white solid: m.p. 147-149.

後処理

  1. washwashed three times with 25 ml of water
  2. dry with materialThe organic layer was dried over magnesium sulfate
  3. filtrationfiltered
  4. customthe solvent removed in vacuo

出典と根拠

ORDレコード
ord-18ad80c939544841a8efc2b5a2efef8f
出典データセット
uspto-grants-1995_06
特許番号
US05424333

関連ノート

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