化工社化工社 化学情報印刷レポート · 研究参考用
Glycine ethyl ester → HCID 59225865、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Glycine ethyl ester | HCID 12176 | — |
| 反応物 | Ethyl glycylglycinate | HCID 124706 | — |
| 反応物 | HCID 46178862 | HCID 46178862 | — |
| 反応物 | 2-(2-(5-bromo-1-(4-cyanonaphthalen-1-yl)-1H-imidazol-2-ylthio)acetamido)acetic acid | HCID 59225886 | — |
| 生成物 | HCID 59225865 | HCID 59225865 | — |
反応手順
2-(2-(2-(5-bromo-1-(4-cyanonaphthalen-1-yl)-1H-imidazol-2-ylthio)acetamido)acetamido)acetic acid is prepared via either of the two routes shown below. In the first, 2-(2-(5-bromo-1-(4-cyanonaphthalen-1-yl)-1H-imidazol-2-ylthio)acetamido)acetic acid (see eg 3) is coupled with glycine ethyl ester and then hydrolyzed to the acid. In the second, 2-(5-bromo-1-(4-cyanonaphthalen-1-yl)-1H-imidazol-2-ylthio)acetic acid (see eg 1) is coupled with NH2-Gly-Gly-OEt, which is then hydrolyzed to the acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08193234B2 |
| 出典データセット | uspto-grants-2012_06 |
| ORD ID | ord-648304722cd14c4a87384e370a68add6 |
| 出典メモ | uspto-grants-2012_06 |