Ethoxyethylamine → N-(2-Ethoxyethyl)-3-nitropyridin-2-amine

HRID 2166122ノート

反応式

HRID 2166122 の反応式
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH2:11]([O:13][CH2:14][CH2:15][NH2:16])[CH3:12].C(=O)([O-])O.[Na+]>C(O)C>[CH2:11]([O:13][CH2:14][CH2:15][NH:16][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1)[CH3:12]

参加物

5

反応物 3

HCID 66970EthoxyethylamineHCID 796132-Chloro-3-nitropyridineHCID 516892Sodium Bicarbonate

生成物 1

HCID 15718757N-(2-Ethoxyethyl)-3-nitropyridin-2-amine収率 100%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 19 parts of 2-chloro-3-nitropyridine, 13.5 parts of 2-ethoxyethanamine, 13 parts of sodium hydrogen carbonate and 240 parts of ethanol was stirred for 6 hours at reflux temperature. After cooling, the mixture was filtered over diatomaceous earth and the filtrate was evaporated, yielding 25.5 parts (100%) of N-(2-ethoxyethyl)-3-nitro-2-pyridinamine as a residue (interm. 8).

後処理

  1. temperatureat reflux temperature
  2. temperatureAfter cooling
  3. filtrationthe mixture was filtered over diatomaceous earth
  4. customthe filtrate was evaporated

出典と根拠

ORDレコード
ord-0609d0acf0f1408b97b6bf6148c314cc
出典データセット
uspto-grants-1990_07
特許番号
US04943580

反応ノート

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