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Potassium Carbonate → N-benzoyl-N'-t-butyl-N'-(ethoxycarbonyl)methylhydrazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1-Acetoxy-2-bromoethane | HCID 13564 | — |
| 反応物 | N'-tert-butylbenzohydrazide | HCID 299436 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | N-benzoyl-N'-t-butyl-N'-(ethoxycarbonyl)methylhydrazine | HCID 15452013 | 9.4% |
反応手順
N'-t-butyl-N-benzoylhydrazine (2.0 g), powdered potassium carbonate (5 g) and bromoethyl acetate (1.6 g) were stirred in dimethylformamide (20 ml) at 60° C. for 14 hours. The reaction mixture was diluted with water and ether, and the organic layer was separated. The organic layer was washed several times with water, dried over magnesium sulfate and rotavapped to afford an oil. Chromatographic purification gave the pure oil product (0.25 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05424333 |
| 出典データセット | uspto-grants-1995_06 |
| ORD ID | ord-037e49102d464965acd586fc010b4458 |
| 出典メモ | uspto-grants-1995_06 |