Veratryl chloride → HCID 14499767、化合物

HRID 2166376ノート

反応式

HRID 2166376 の反応式
[N:1]1[CH:6]=[CH:5][C:4]([C:7]([N:9]2[CH2:18][CH2:17][C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH2:10]2)=[O:8])=[CH:3][CH:2]=1.[CH3:19][O:20][C:21]1[CH:22]=[C:23]([CH:26]=[CH:27][C:28]=1[O:29][CH3:30])[CH2:24][Cl:25]>C(OCC)(=O)C>[Cl-:25].[CH3:19][O:20][C:21]1[CH:22]=[C:23]([CH2:24][N+:1]2[CH:2]=[CH:3][C:4]([C:7]([N:9]3[CH2:18][CH2:17][C:16]4[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=4)[CH2:10]3)=[O:8])=[CH:5][CH:6]=2)[CH:26]=[CH:27][C:28]=1[O:29][CH3:30]

参加物

4

反応物 2

HCID 81740Veratryl chlorideHCID 4137929HCID 4137929、化合物

生成物 1

HCID 14499767HCID 14499767、化合物

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of 4.76 g (20 mmol) of 2-[(4-pyridyl)carbonyl]-1,2,3,4-tetrahydroisoquinoline, 4.5 g (24 mmol) of 3,4-dimethoxybenzyl chloride and 200 ml of ethyl acetate is heated under reflux for 20 h. The mixture obtained is allowed to cool, and the precipitate is separated off by filtration and washed with ether. 6.6 g of salt are collected, this being used without further purification in the following stage.

後処理

  1. temperatureis heated
  2. temperatureunder reflux for 20 h
  3. customThe mixture obtained
  4. temperatureto cool
  5. customthe precipitate is separated off by filtration
  6. washwashed with ether
  7. custom6.6 g of salt are collected
  8. customthis being used without further purification in the following stage

出典と根拠

ORDレコード
ord-7acb3d3a9b834bdb9ed5864ba5631ab7
出典データセット
uspto-grants-1990_07
特許番号
US04945096

反応ノート

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