Lactic Acid → 1-Carboxyethyl 4-(2-cyclohexylethylamino)phenylacetate

HRID 2166783ノート

反応式

HRID 2166783 の反応式
[CH:1]1([CH2:7][CH2:8][NH:9][C:10]2[CH:15]=[CH:14][C:13]([CH2:16][C:17]([OH:19])=[O:18])=[CH:12][CH:11]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:20]([OH:25])(=[O:24])[CH:21]([CH3:23])O.C1(C)C(S(O)(=O)=O)=CC=CC=1>C1(C)C=CC=CC=1>[CH:1]1([CH2:7][CH2:8][NH:9][C:10]2[CH:15]=[CH:14][C:13]([CH2:16][C:17]([O:19][CH:21]([C:20]([OH:25])=[O:24])[CH3:23])=[O:18])=[CH:12][CH:11]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

5

反応物 3

HCID 612Lactic AcidHCID 69252-Methylbenzenesulfonic acidHCID 204989854-(2-Cyclohexylethylamino)phenylacetic acid

生成物 1

HCID 204989661-Carboxyethyl 4-(2-cyclohexylethylamino)phenylacetate

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A flask containing 10.0 g. 4-(2-cyclohexylethylamino)phenylacetic acid, 3.3 g. lactic acid, 500 mg. toluenesulfonic acid and 500 ml. toluene equipped with a Soxhlet extractor charged with activated 4 A Linde molecular sieves. The solution is refluxed for 24 hours during which time the Soxhlet extractor is charged twice more with fresh sieves. The hot solution is filtered and left to cool, whereupon 1-carboxyethyl 4-(2-cyclohexylethylamino)phenylacetate separates as off-white crystals.

後処理

  1. additionA flask containing 10.0 g
  2. additioncharged
  3. temperatureThe solution is refluxed for 24 hours during which time the Soxhlet extractor
  4. additionis charged twice more with fresh sieves
  5. filtrationThe hot solution is filtered
  6. waitleft
  7. temperatureto cool, whereupon 1-carboxyethyl 4-(2-cyclohexylethylamino)phenylacetate

出典と根拠

ORDレコード
ord-8d82bec79b614671baf3ccf1317ba36d
出典データセット
uspto-grants-1983_06
特許番号
US04388459

反応ノート

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