Clonidine → 1H-Imidazol-2-amine, 4,5-dihydro-N-(2,6-dichlorophenyl)-1-(3-pyridinylcarbonyl)-

HRID 2166825ノート

反応式

HRID 2166825 の反応式
[C:1](C1[N-]C=CN=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1.[Cl:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([Cl:21])[C:16]=1[NH:22][C:23]1[NH:24][CH2:25][CH2:26][N:27]=1>C1(C)C=CC=CC=1>[C:1]([N:27]1[CH2:26][CH2:25][N:24]=[C:23]1[NH:22][C:16]1[C:17]([Cl:21])=[CH:18][CH:19]=[CH:20][C:15]=1[Cl:14])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1

参加物

4

反応物 2

HCID 2803ClonidineHCID 178519683HCID 178519683、化合物

生成物 1

HCID 30619571H-Imidazol-2-amine, 4,5-dihydro-N-(2,6-dichlorophenyl)-1-(3-pyridinylcarbonyl)-収率 43.3%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

4.15 g (24 millimoles) of nicotinoylimidazolide and 4.6 g (20 millimoles) of 2-(2',6'-dichlorophenylamino)-2-imidazoline in 100 ml of absolute toluene are refluxed for 3 hours. The mixture is then concentrated to dryness on a rotary evaporator and the residue is worked up as described in Example 41. 2.9 g of pure 1-nicotinoyl-2-(2',6'-dichlorophenylamino)-2-imidazoline of melting point 172.5°-173.5° C. are obtained; the material is identical with the product obtained according to Example 1.

後処理

  1. concentrationThe mixture is then concentrated to dryness on a rotary evaporator

出典と根拠

ORDレコード
ord-31690a3a0a6d400bbc7ab05e6622f6dc
出典データセット
uspto-grants-1983_06
特許番号
US04389403

反応ノート

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