Clonidine → 1H-Imidazol-2-amine, 4,5-dihydro-N-(2,6-dichlorophenyl)-1-(2-quinolinylcarbonyl)-

反応式

[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:11](C1[N-]C=CN=1)=[O:12].[Cl:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[C:20]=1[NH:26][C:27]1[NH:28][CH2:29][CH2:30][N:31]=1>>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:11]([N:31]1[CH2:30][CH2:29][N:28]=[C:27]1[NH:26][C:20]1[C:21]([Cl:25])=[CH:22][CH:23]=[CH:24][C:19]=1[Cl:18])=[O:12]

参加物

反応物 2

HCID 2803Clonidine

HCID 178519315HCID 178519315、化合物

生成物 1

HCID 30619581H-Imidazol-2-amine, 4,5-dihydro-N-(2,6-dichlorophenyl)-1-(2-quinolinylcarbonyl)-収率 84.4%

実験手順

Using the process described in Example 57, 5.36 g (24 millimoles) of quinolin-2-oyl-imidazolide and 4.6 g (20 millimoles) of 2-(2',6'-dichlorophenylamino)-2-imidazoline give 6.5 g of pure 1-(quinolin-2-oyl)-2-(2',6'-dichlorophenylamino)-2-imidazoline of melting point 193.5°-196° C.; the material is identical with the product obtained according to Example 45.

出典と根拠

ORDレコード: ord-65b7fee4ebf4494c86248684c7a4e6ef
出典データセット: uspto-grants-1983_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04389403

反応ノート

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